HS3ST5

Entrez Summary: N/A
UniProt Summary: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. Also generates GlcUA- GlcNS or IdoUA-GlcNS and IdoUA2S-GlcNH2. The substrate-specific O- sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. {ECO:0000269|PubMed:12138164}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

3-phosphoadenosine 5-phosphosulfate binding
heparan sulfate proteoglycan biosynthetic process, enzymatic modification
protein sulfation
[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity
heparan sulfate sulfotransferase activity
sulfation
heparan sulfate proteoglycan biosynthetic process
regulation of viral entry into host cell
heparan sulfate proteoglycan metabolic process
negative regulation of coagulation
proteoglycan biosynthetic process
regulation of coagulation
proteoglycan metabolic process
glycosaminoglycan biosynthetic process
aminoglycan biosynthetic process
regulation of viral life cycle
glycosaminoglycan metabolic process
aminoglycan metabolic process
regulation of viral process
regulation of symbiosis, encompassing mutualism through parasitism
glycoprotein biosynthetic process
sulfur compound metabolic process
glycoprotein metabolic process
Golgi membrane
carbohydrate derivative biosynthetic process
regulation of multi-organism process
carbohydrate derivative metabolic process
negative regulation of multicellular organismal process
organonitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process