IGF2BP2

Entrez Summary: This gene encodes a protein that binds the 5' UTR of insulin-like growth factor 2 (IGF2) mRNA and regulates its translation. It plays an important role in metabolism and variation in this gene is associated with susceptibility to diabetes. Alternative splicing and promoter usage results in multiple transcript variants. Related pseudogenes are found on several chromosomes. [provided by RefSeq, Sep 2016].
UniProt Summary: RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta- actin/ACTB and MYC transcripts. {ECO:0000250, ECO:0000269|PubMed:23640942, ECO:0000269|PubMed:9891060}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

RRM 1
KH 1

translation regulator activity
mRNA 5-UTR binding
mRNA 3-UTR binding
regulation of cytokine biosynthetic process
negative regulation of translation
negative regulation of cellular amide metabolic process
mRNA transport
regulation of mRNA stability
regulation of RNA stability
RNA transport
nucleic acid transport
establishment of RNA localization
regulation of mRNA catabolic process
RNA localization
nucleobase-containing compound transport
regulation of mRNA metabolic process
regulation of translation
cytoskeleton
regulation of cellular amide metabolic process
posttranscriptional regulation of gene expression
regulation of cytokine production
regulation of cellular catabolic process
regulation of catabolic process
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
negative regulation of cellular macromolecule biosynthetic process
RNA binding
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
negative regulation of gene expression
nitrogen compound transport