IL23R
Gene Information
- Official Symbol: IL23R
- Official Name: interleukin 23 receptor
- Aliases and Previous Symbols: N/A
- Entrez ID: 149233
- UniProt: Q5VWK5
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. [provided by RefSeq, Jul 2008].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| interleukin-23 receptor activity |
| interleukin-23 binding |
| interleukin-23 receptor complex |
| positive regulation of T-helper 17 cell lineage commitment |
| regulation of T-helper 17 cell lineage commitment |
| positive regulation of memory T cell differentiation |
| interleukin-12 receptor binding |
| positive regulation of activation of Janus kinase activity |
| positive regulation of natural killer cell proliferation |
| positive regulation of T-helper 17 cell differentiation |
| positive regulation of NK T cell activation |
| regulation of activation of Janus kinase activity |
| regulation of natural killer cell proliferation |
| regulation of memory T cell differentiation |
| positive regulation of cell fate commitment |
| interleukin-23-mediated signaling pathway |
| positive regulation of T-helper 17 type immune response |
| regulation of NK T cell activation |
| positive regulation of granulocyte macrophage colony-stimulating factor production |
| regulation of granulocyte macrophage colony-stimulating factor production |
| positive regulation of interleukin-17 production |
| regulation of T-helper 17 cell differentiation |
| negative regulation of interleukin-10 production |
| regulation of T-helper 17 type immune response |
| positive regulation of natural killer cell activation |
| positive regulation of T-helper 1 type immune response |
| positive regulation of T-helper cell differentiation |
| positive regulation of activated T cell proliferation |
| positive regulation of defense response to virus by host |
| positive regulation of T cell mediated cytotoxicity |
| positive regulation of osteoclast differentiation |
| regulation of T-helper 1 type immune response |
| regulation of cell fate commitment |
| regulation of interleukin-17 production |
| positive regulation of CD4-positive, alpha-beta T cell differentiation |
| regulation of natural killer cell activation |
| regulation of T cell mediated cytotoxicity |
| regulation of T-helper cell differentiation |
| positive regulation of CD4-positive, alpha-beta T cell activation |
| positive regulation of interleukin-12 production |
| regulation of activated T cell proliferation |
| regulation of defense response to virus by host |
| cytokine binding |
| regulation of CD4-positive, alpha-beta T cell differentiation |
| positive regulation of alpha-beta T cell differentiation |
| cytokine receptor activity |
| positive regulation of T cell mediated immunity |
| regulation of interleukin-10 production |
| regulation of interleukin-12 production |
| positive regulation of leukocyte mediated cytotoxicity |
| positive regulation of myeloid leukocyte differentiation |
| regulation of CD4-positive, alpha-beta T cell activation |
| positive regulation of alpha-beta T cell activation |
| regulation of alpha-beta T cell differentiation |
| positive regulation of interferon-gamma production |
| regulation of osteoclast differentiation |
| positive regulation of cell killing |
| positive regulation of tyrosine phosphorylation of STAT protein |
| regulation of T cell mediated immunity |
| regulation of defense response to virus |
| regulation of leukocyte mediated cytotoxicity |
| regulation of tyrosine phosphorylation of STAT protein |
| positive regulation of T cell differentiation |
| defense response to Gram-negative bacterium |
| positive regulation of receptor signaling pathway via JAK-STAT |
| positive regulation of receptor signaling pathway via STAT |
| positive regulation of myeloid cell differentiation |
| regulation of alpha-beta T cell activation |
| positive regulation of lymphocyte differentiation |
| positive regulation of T cell proliferation |
| regulation of interferon-gamma production |
| positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| regulation of cell killing |
| positive regulation of lymphocyte mediated immunity |
| positive regulation of adaptive immune response |
| regulation of myeloid leukocyte differentiation |
| positive regulation of lymphocyte proliferation |
| regulation of receptor signaling pathway via JAK-STAT |
| positive regulation of mononuclear cell proliferation |
| positive regulation of leukocyte mediated immunity |
| regulation of receptor signaling pathway via STAT |
| positive regulation of leukocyte proliferation |
| regulation of T cell differentiation |
| regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| positive regulation of leukocyte differentiation |
| regulation of lymphocyte mediated immunity |
| regulation of T cell proliferation |
| regulation of adaptive immune response |
| regulation of lymphocyte differentiation |
| response to interferon-gamma |
| positive regulation of hemopoiesis |
| positive regulation of peptidyl-tyrosine phosphorylation |
| positive regulation of T cell activation |
| receptor complex |
| regulation of leukocyte mediated immunity |
| regulation of lymphocyte proliferation |
| regulation of mononuclear cell proliferation |
| positive regulation of leukocyte cell-cell adhesion |
| positive regulation of immune effector process |
| regulation of leukocyte proliferation |
| regulation of myeloid cell differentiation |
| regulation of peptidyl-tyrosine phosphorylation |
| positive regulation of cell-cell adhesion |
| regulation of leukocyte differentiation |
| negative regulation of cytokine production |
| regulation of leukocyte cell-cell adhesion |
| response to lipopolysaccharide |
| regulation of T cell activation |
| response to molecule of bacterial origin |
| defense response to bacterium |
| positive regulation of lymphocyte activation |
| external side of plasma membrane |
| regulation of cell-cell adhesion |
| positive regulation of leukocyte activation |
| positive regulation of cell adhesion |
| positive regulation of cell activation |
| positive regulation of cytokine production |
| regulation of hemopoiesis |
| regulation of immune effector process |
| inflammatory response |
| regulation of lymphocyte activation |
| regulation of response to biotic stimulus |
| positive regulation of protein kinase activity |
| positive regulation of kinase activity |
| regulation of leukocyte activation |
| regulation of cell activation |
| positive regulation of transferase activity |
| cytokine-mediated signaling pathway |
| regulation of cell adhesion |
| response to bacterium |
| regulation of cytokine production |
| regulation of defense response |
| innate immune response |
| regulation of multi-organism process |
| regulation of protein kinase activity |
| response to lipid |
| positive regulation of immune response |
| regulation of kinase activity |
| positive regulation of cell population proliferation |
| defense response to other organism |
| positive regulation of cell differentiation |
| regulation of transferase activity |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| positive regulation of phosphorylation |
| regulation of response to external stimulus |
| response to cytokine |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of immune system process |
| regulation of immune response |
| negative regulation of multicellular organismal process |
| positive regulation of protein modification process |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| positive regulation of developmental process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of response to stress |
| response to oxygen-containing compound |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| regulation of immune system process |
| positive regulation of signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of protein modification process |
| immune response |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HGC6.3 | 0.494 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 11241
- Expression level (log2 read counts): 1.92
Expression Distribution
IL23R Expression in NALM6 Cells: 1.92
