IMPACT

Gene Information

Official Symbol: IMPACT
Official Name: impact RWD domain protein
Aliases and Previous Symbols: N/A
Entrez ID: 55364
UniProt: Q9P2X3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1- mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis. Through its inhibitory action on EIF2AK4/GCN2, plays a role in differentiation of neuronal cells by stimulating neurite outgrowth. {ECO:0000250|UniProtKB:O55091}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14244
Expression level (log2 read counts): 1.11

Expression Distribution

RWD
UPF0029

response to benomyl
cellular response to benomyl
regulation of eIF2 alpha phosphorylation by amino acid starvation
positive regulation of translational initiation in response to starvation
regulation of translational initiation in response to starvation
positive regulation of translational initiation in response to stress
positive regulation of translation in response to stress
cellular response to UV-C
cellular response to leucine starvation
regulation of translational initiation in response to stress
response to fungicide
cellular response to acidic pH
negative regulation of transcription from RNA polymerase II promoter in response to stress
negative regulation of protein autophosphorylation
response to UV-C
regulation of translation in response to stress
response to acidic pH
cellular response to pH
positive regulation of translational initiation
response to pH
cellular response to glucose starvation
cellular response to amino acid starvation
polysome
response to amino acid starvation
regulation of protein autophosphorylation
ribosome binding
neuron projection extension
cellular response to hydrogen peroxide
regulation of translational initiation
cellular response to UV
developmental cell growth
cell growth
cellular response to light stimulus
developmental growth involved in morphogenesis
cellular response to antibiotic
response to hydrogen peroxide
regulation of transcription from RNA polymerase II promoter in response to stress
positive regulation of translation
regulation of DNA-templated transcription in response to stress
negative regulation of protein complex assembly