IQGAP2

Entrez Summary: This gene encodes a member of the IQGAP family. The encoded protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. This protein interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. It also acts as a tumor suppressor and has been found to play a role in regulating innate antiviral responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017].
UniProt Summary: Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Arp2/3 complex binding
thrombin-activated receptor signaling pathway
GTPase inhibitor activity
Arp2/3 complex-mediated actin nucleation
Rho GTPase binding
actin nucleation
phosphatidylinositol-3,4,5-trisphosphate binding
negative regulation of GTPase activity
Rac GTPase binding
microvillus
filopodium
positive regulation of actin filament polymerization
secretory granule membrane
positive regulation of protein polymerization
regulation of actin filament polymerization
lamellipodium
regulation of actin polymerization or depolymerization
regulation of actin filament length
positive regulation of supramolecular fiber organization
calmodulin binding
actin filament binding
actin cytoskeleton
positive regulation of cytoskeleton organization
regulation of protein polymerization
actin filament organization
positive regulation of protein complex assembly
regulation of actin filament organization
actin binding
regulation of actin cytoskeleton organization
regulation of supramolecular fiber organization
regulation of cellular component size
regulation of actin filament-based process
regulation of protein complex assembly
negative regulation of hydrolase activity
supramolecular fiber organization
regulation of GTPase activity
neutrophil degranulation
neutrophil activation involved in immune response
actin cytoskeleton organization
neutrophil mediated immunity