IQSEC2

Gene Information
  • Official Symbol: IQSEC2
  • Official Name: IQ motif and Sec7 domain ArfGEF 2
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 23096
  • UniProt: Q5JU85
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: This gene encodes a guanine nucleotide exchange factor for the ARF family of small GTP-binding proteins. The encoded protein is a component of the postsynaptic density at excitatory synapses, and may play a critical role in cytoskeletal and synaptic organization through the activation of selected ARF substrates including ARF1 and ARF6. Mutations in this gene have been implicated in nonsyndromic X-linked cognitive disability. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011].
  • UniProt Summary: Is a guanine nucleotide exchange factor for the ARF GTP- binding proteins. {ECO:0000269|PubMed:26793055}.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 6303
  • Expression level (log2 read counts): -0.46

Expression Distribution

  • Last modified: 2025/12/10 20:19
  • by 127.0.0.1