IRGM

Gene Information

Official Symbol: IRGM
Official Name: immunity related GTPase M
Aliases and Previous Symbols: N/A
Entrez ID: 345611
UniProt: A1A4Y4
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2016].
UniProt Summary: Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility (By similarity). {ECO:0000250, ECO:0000269|PubMed:16888103}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18285
Expression level (log2 read counts): 0.43

Expression Distribution

protein lipidation involved in autophagosome assembly
CAMKK-AMPK signaling cascade
calmodulin dependent kinase signaling pathway
BH3 domain binding
modulation by symbiont of host autophagy
positive regulation of interferon-gamma-mediated signaling pathway
positive regulation by symbiont of host autophagy
C-terminal protein lipidation
positive regulation of response to interferon-gamma
positive regulation of autophagosome maturation
nucleotide-binding oligomerization domain containing 2 signaling pathway
regulation of protein complex stability
regulation of autophagosome maturation
C-terminal protein amino acid modification
CARD domain binding
cellular response to interferon-beta
regulation of response to interferon-gamma
regulation of interferon-gamma-mediated signaling pathway
modulation by symbiont of host cellular process
nucleotide-binding oligomerization domain containing signaling pathway
phagocytic cup
nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
response to interferon-beta
protein serine/threonine kinase activator activity
positive regulation of peptidyl-threonine phosphorylation
cellular response to virus
autophagosome membrane
cytoplasmic pattern recognition receptor signaling pathway
positive regulation of protein complex disassembly
modification by symbiont of host morphology or physiology
regulation of peptidyl-threonine phosphorylation
protein destabilization
positive regulation of cytokine-mediated signaling pathway
positive regulation of response to cytokine stimulus
autophagosome assembly
autophagosome organization
positive regulation of macroautophagy
phagocytic vesicle membrane
defense response to Gram-negative bacterium
protein lipidation