ITGB1BP2
Gene Information
- Official Symbol: ITGB1BP2
- Official Name: integrin subunit beta 1 binding protein 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 26548
- UniProt: Q9UKP3
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a protein with two cysteine and histidine-rich (CHORD) domains, PXXP motifs, YXXI/P motifs, putative SH2 and SH3 domain binding motifs, and an acidic region at the C-terminus that can bind calcium. Two hybrid analysis showed that this protein interacts with the cytoplasmic domain of the beta 1 integrin subunit and is thought to act as a chaperone protein. Studies in the mouse ortholog of this gene indicate that absence of this gene in mouse results in failed cardiac hypertrophy in response to mechanical stress. Alternative splicing results in multiple transcript variants encoding different isoforms, including an isoform that lacks several domains, including one of the CHORD domains. [provided by RefSeq, May 2017].
- UniProt Summary: May play a role during maturation and/or organization of muscles cells.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 13721
- Expression level (log2 read counts): 2.67
ITGB1BP2 Expression in NALM6 Cells: 2.67
