KIAA1462

Gene Information

Official Symbol: JCAD
Official Name: junctional cadherin 5 associated
Aliases and Previous Symbols: N/A
Entrez ID: 57608
UniProt: Q9P266
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes an endothelial cell-to-cell junction protein. Naturally occurring mutations in this gene are associated with coronary artery disease, late onset alzheimer disease, and emphysema distribution. [provided by RefSeq, Mar 2017].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13740
Expression level (log2 read counts): 1.21

Expression Distribution

positive regulation of vascular endothelial growth factor signaling pathway
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
regulation of vascular endothelial growth factor signaling pathway
regulation of cellular response to vascular endothelial growth factor stimulus
positive regulation of cell migration involved in sprouting angiogenesis
regulation of cell migration involved in sprouting angiogenesis
positive regulation of sprouting angiogenesis
positive regulation of blood vessel endothelial cell migration
adherens junction
regulation of sprouting angiogenesis
regulation of blood vessel endothelial cell migration
positive regulation of endothelial cell proliferation
ruffle membrane
positive regulation of endothelial cell migration
regulation of endothelial cell proliferation
positive regulation of epithelial cell migration
regulation of endothelial cell migration
positive regulation of angiogenesis
cell-cell junction
positive regulation of vasculature development
positive regulation of epithelial cell proliferation
regulation of epithelial cell migration
regulation of cellular response to growth factor stimulus
regulation of angiogenesis
regulation of vasculature development
regulation of epithelial cell proliferation
positive regulation of cell migration
positive regulation of cell motility
positive regulation of cellular component movement
positive regulation of MAPK cascade
positive regulation of locomotion
perinuclear region of cytoplasm
regulation of MAPK cascade
regulation of cell migration
regulation of cell motility
positive regulation of cell population proliferation
cell adhesion
biological adhesion
regulation of locomotion