LACRT
Gene Information
- Official Symbol: LACRT
- Official Name: lacritin
- Aliases and Previous Symbols: N/A
- Entrez ID: 90070
- UniProt: Q9GZZ8
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Modulates secretion by lacrimal acinar cells.
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| tear secretion |
| laminin-1 binding |
| positive regulation of epithelial cell proliferation involved in wound healing |
| calcineurin-NFAT signaling cascade |
| negative regulation of lipopolysaccharide-mediated signaling pathway |
| calcineurin-mediated signaling |
| positive regulation of calcineurin-mediated signaling |
| positive regulation of calcineurin-NFAT signaling cascade |
| secretion by tissue |
| inositol phosphate-mediated signaling |
| regulation of lipopolysaccharide-mediated signaling pathway |
| epithelial structure maintenance |
| fibronectin binding |
| protein localization to Golgi apparatus |
| regulation of calcineurin-mediated signaling |
| regulation of calcineurin-NFAT signaling cascade |
| positive regulation of release of sequestered calcium ion into cytosol |
| positive regulation of calcium-mediated signaling |
| positive regulation of calcium ion transport into cytosol |
| collagen binding |
| positive regulation of macroautophagy |
| positive regulation of calcium ion transmembrane transport |
| body fluid secretion |
| regulation of release of sequestered calcium ion into cytosol |
| secretory granule |
| negative regulation of response to biotic stimulus |
| regulation of calcium-mediated signaling |
| regulation of calcium ion transport into cytosol |
| protein N-terminus binding |
| positive regulation of autophagy |
| positive regulation of calcium ion transport |
| regulation of sequestering of calcium ion |
| positive regulation of cation transmembrane transport |
| protein acetylation |
| calcium-mediated signaling |
| regulation of calcium ion transmembrane transport |
| positive regulation of ion transmembrane transport |
| growth factor activity |
| regulation of macroautophagy |
| protein acylation |
| positive regulation of epithelial cell proliferation |
| tissue homeostasis |
| positive regulation of peptidyl-tyrosine phosphorylation |
| positive regulation of transmembrane transport |
| negative regulation of multi-organism process |
| regulation of calcium ion transport |
| regulation of peptidyl-tyrosine phosphorylation |
| positive regulation of ion transport |
| positive regulation of cytosolic calcium ion concentration |
| multicellular organismal homeostasis |
| regulation of cytosolic calcium ion concentration |
| defense response to bacterium |
| regulation of autophagy |
| regulation of epithelial cell proliferation |
| regulation of cation transmembrane transport |
| second-messenger-mediated signaling |
| anatomical structure homeostasis |
| negative regulation of response to external stimulus |
| positive regulation of cellular catabolic process |
| regulation of metal ion transport |
| positive regulation of catabolic process |
| positive regulation of secretion |
| cellular calcium ion homeostasis |
| calcium ion homeostasis |
| cellular divalent inorganic cation homeostasis |
| regulation of ion transmembrane transport |
| wound healing |
| divalent inorganic cation homeostasis |
| regulation of body fluid levels |
| regulation of response to biotic stimulus |
| cellular metal ion homeostasis |
| regulation of transmembrane transport |
| response to wounding |
| metal ion homeostasis |
| cellular cation homeostasis |
| cellular ion homeostasis |
| response to bacterium |
| regulation of ion transport |
| cation homeostasis |
| inorganic ion homeostasis |
| protein localization to organelle |
| cellular chemical homeostasis |
| regulation of multi-organism process |
| ion homeostasis |
| regulation of secretion |
| regulation of cellular catabolic process |
| negative regulation of apoptotic process |
| cellular homeostasis |
| negative regulation of programmed cell death |
| positive regulation of cell population proliferation |
| regulation of cellular localization |
| defense response to other organism |
| positive regulation of transport |
| regulation of catabolic process |
| negative regulation of cell death |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| positive regulation of phosphorylation |
| regulation of response to external stimulus |
| chemical homeostasis |
| secretion |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| positive regulation of protein modification process |
| negative regulation of signal transduction |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| negative regulation of cell communication |
| negative regulation of signaling |
| regulation of protein phosphorylation |
| regulation of apoptotic process |
| regulation of programmed cell death |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| homeostatic process |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
| extracellular region |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12044
- Expression level (log2 read counts): -7.68
Expression Distribution
LACRT Expression in NALM6 Cells: -7.68
