LCE2A

Entrez Summary: N/A
UniProt Summary: Precursors of the cornified envelope of the stratum corneum.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Trientine 500μM R08 exp534	-2.06
CVT-10216 0.1μM R06 exp278	-1.89
Pimelic-diphenylamide-106 5μM R00 exp28	-1.85
TIC10 10μM R08 exp532	-1.83
Rotenone 0.07μM R08 exp431	-1.78
Atovaquone 15μM R08 exp451	-1.72
Docetaxel 0.002μM R01 exp45	2.37

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

peptide cross-linking
cornified envelope
structural molecule activity
keratinization
keratinocyte differentiation
epidermal cell differentiation
skin development
epidermis development
epithelial cell differentiation
epithelium development
tissue development