LHX6

Entrez Summary: This gene encodes a member of a large protein family that contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein has tandem LIM domains as well as a DNA-binding homeodomain. The protein functions as a transcription factor involved in embryogenesis and head development and is highly expressed in neural crest derived mesenchyme cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2017].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Homeobox
LIM

interneuron migration
cerebral cortex GABAergic interneuron migration
cerebral cortex GABAergic interneuron development
cerebral cortex tangential migration
interneuron migration from the subpallium to the cortex
cerebral cortex GABAergic interneuron differentiation
substrate-independent telencephalic tangential interneuron migration
substrate-independent telencephalic tangential migration
GABAergic neuron differentiation
cerebral cortex neuron differentiation
cerebral cortex radially oriented cell migration
forebrain neuron development
cerebral cortex cell migration
forebrain neuron differentiation
telencephalon cell migration
forebrain cell migration
forebrain generation of neurons
central nervous system neuron development
cerebral cortex development
neuron migration
cell maturation
pallium development
central nervous system neuron differentiation
developmental maturation
telencephalon development
RNA polymerase II regulatory region sequence-specific DNA binding
forebrain development
DNA-binding transcription factor activity
brain development
head development
neuron development
cell migration
central nervous system development
neuron differentiation
cell motility
localization of cell
positive regulation of transcription by RNA polymerase II
locomotion
generation of neurons
positive regulation of transcription, DNA-templated