LIPG
Gene Information
- Official Symbol: LIPG
- Official Name: lipase G, endothelial type
- Aliases and Previous Symbols: N/A
- Entrez ID: 9388
- UniProt: Q9Y5X9
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Has phospholipase and triglyceride lipase activities. Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins. Binds heparin.
Pfam Domains GO Terms
Pfam Domains
| PLAT |
| Abhydrolase 6 |
| Lipase |
GO Terms
| positive regulation of high-density lipoprotein particle clearance |
| lipoprotein lipase activity |
| regulation of high-density lipoprotein particle clearance |
| positive regulation of lipoprotein particle clearance |
| phospholipase A1 activity |
| very-low-density lipoprotein particle remodeling |
| phospholipid homeostasis |
| regulation of lipoprotein metabolic process |
| triglyceride-rich lipoprotein particle remodeling |
| reverse cholesterol transport |
| phospholipase activity |
| high-density lipoprotein particle remodeling |
| regulation of lipoprotein particle clearance |
| lipase activity |
| positive regulation of cholesterol transport |
| positive regulation of sterol transport |
| triglyceride catabolic process |
| protein-lipid complex remodeling |
| plasma lipoprotein particle remodeling |
| protein-containing complex remodeling |
| acylglycerol catabolic process |
| phospholipid catabolic process |
| acylglycerol homeostasis |
| triglyceride homeostasis |
| neutral lipid catabolic process |
| plasma lipoprotein particle organization |
| regulation of cholesterol transport |
| regulation of sterol transport |
| protein-lipid complex subunit organization |
| glycerolipid catabolic process |
| cholesterol transport |
| anion homeostasis |
| positive regulation of lipid transport |
| sterol transport |
| regulation of plasma lipoprotein particle levels |
| triglyceride metabolic process |
| cholesterol homeostasis |
| sterol homeostasis |
| positive regulation of lipid localization |
| acylglycerol metabolic process |
| neutral lipid metabolic process |
| regulation of lipid transport |
| fatty acid biosynthetic process |
| organophosphate catabolic process |
| lipid homeostasis |
| organic hydroxy compound transport |
| regulation of lipid localization |
| heparin binding |
| monocarboxylic acid biosynthetic process |
| cellular lipid catabolic process |
| response to nutrient |
| early endosome |
| lipid transport |
| lipid catabolic process |
| carboxylic acid biosynthetic process |
| organic acid biosynthetic process |
| lipid localization |
| fatty acid metabolic process |
| phospholipid metabolic process |
| glycerolipid metabolic process |
| extracellular structure organization |
| response to nutrient levels |
| monocarboxylic acid metabolic process |
| response to extracellular stimulus |
| cell population proliferation |
| lipid biosynthetic process |
| small molecule biosynthetic process |
| cell surface |
| ion homeostasis |
| organophosphate metabolic process |
| carboxylic acid metabolic process |
| cellular lipid metabolic process |
| Golgi apparatus |
| positive regulation of transport |
| oxoacid metabolic process |
| organic acid metabolic process |
| chemical homeostasis |
| lipid metabolic process |
| extracellular space |
| homeostatic process |
| positive regulation of multicellular organismal process |
| small molecule metabolic process |
| organic substance catabolic process |
| cellular catabolic process |
| protein-containing complex subunit organization |
| regulation of transport |
| extracellular region |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Lapatinib 5μM R01 exp47 | -1.76 |
| OICR-9429 10μM R03 exp142 | 1.85 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15375
- Expression level (log2 read counts): 4.51
Expression Distribution
LIPG Expression in NALM6 Cells: 4.51
