MAGEA2

Gene Information

Official Symbol: MAGEA2
Official Name: MAGE family member A2
Aliases and Previous Symbols: N/A
Entrez ID: 4101
UniProt: P43356
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T- lymphocytes. Negatively regulates acetylation and sumoylation of PML and represses PML-induced p53/TP53 acetylation and activation. {ECO:0000269|PubMed:16847267, ECO:0000269|PubMed:17942928, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:22117195}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6

Essentiality Rank: 7536
Expression level (log2 read counts): -7.68

Expression Distribution

MAGE
MAGE N

negative regulation of protein sumoylation
negative regulation of protein acetylation
regulation of protein sumoylation
positive regulation of ubiquitin-protein transferase activity
cellular senescence
repressing transcription factor binding
regulation of ubiquitin-protein transferase activity
cell aging
regulation of protein acetylation
negative regulation of protein modification by small protein conjugation or removal
PML body
histone deacetylase binding
positive regulation of protein ubiquitination
signal transduction by p53 class mediator
positive regulation of protein modification by small protein conjugation or removal
regulation of protein ubiquitination
regulation of protein modification by small protein conjugation or removal
aging
ubiquitin protein ligase binding
negative regulation of protein modification process
cellular protein catabolic process
positive regulation of transferase activity
protein catabolic process
negative regulation of transcription by RNA polymerase II
cellular macromolecule catabolic process
regulation of transferase activity
negative regulation of cellular protein metabolic process
macromolecule catabolic process
organonitrogen compound catabolic process
negative regulation of protein metabolic process
negative regulation of transcription, DNA-templated
positive regulation of protein modification process
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
positive regulation of catalytic activity
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process