MBD6

Entrez Summary: N/A
UniProt Summary: Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro).

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Ibrutinib 1μM R07 exp372	-1.74
Trientine 500μM R08 exp534	-1.73

Gene	Correlation
HGC6.3	0.415
SMG1	0.409

chromocenter
fibrillar center
protein deubiquitination
protein modification by small protein removal
chromatin binding
protein modification by small protein conjugation or removal
proteolysis
DNA binding