MED18

Entrez Summary: N/A
UniProt Summary: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 177/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	13/28
blood	9/28
bone	8/25
breast	11/33
central nervous system	8/56
cervix	3/4
colorectal	5/17
esophagus	2/13
fibroblast	0/1
gastric	3/15
kidney	4/21
liver	3/20
lung	19/75
lymphocyte	6/14
ovary	3/26
pancreas	8/24
peripheral nervous system	7/16
plasma cell	7/15
prostate	0/1
skin	3/24
soft tissue	1/7
thyroid	0/2
upper aerodigestive	5/22
urinary tract	4/29
uterus	3/5

Expression Distribution

Screen	Score
BI-6727 0.04μM R03 exp98	1.73
Nocodazole 0.1μM R03 exp94	1.76

core mediator complex
termination of RNA polymerase II transcription
mediator complex
DNA-templated transcription, termination
transcription coregulator activity
transcription by RNA polymerase II
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
gene expression