MIS18BP1

Entrez Summary: N/A
UniProt Summary: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 636/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	23/28
blood	25/28
bone	21/25
breast	29/33
central nervous system	53/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	9/15
kidney	19/21
liver	17/20
lung	68/75
lymphocyte	9/14
ovary	25/26
pancreas	24/24
peripheral nervous system	12/16
plasma cell	14/15
prostate	0/1
skin	20/24
soft tissue	6/7
thyroid	2/2
upper aerodigestive	21/22
urinary tract	24/29
uterus	3/5

Expression Distribution

condensed nuclear chromosome kinetochore
CENP-A containing chromatin organization
CENP-A containing nucleosome assembly
chromatin remodeling at centromere
centromere complex assembly
DNA replication-independent nucleosome assembly
DNA replication-independent nucleosome organization
histone exchange
ATP-dependent chromatin remodeling
nucleosome assembly
chromatin assembly
chromatin assembly or disassembly
nucleosome organization
chromatin remodeling
DNA packaging
protein-DNA complex assembly
protein-DNA complex subunit organization
DNA conformation change
cell division
chromatin organization
cellular protein-containing complex assembly
chromosome organization
cell cycle
DNA binding
protein-containing complex assembly
DNA-binding transcription factor activity, RNA polymerase II-specific
protein-containing complex subunit organization