MMP21

Entrez Summary: This gene encodes a member of the matrix metalloproteinase family. Proteins in this family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, and disease processes, such as asthma and tumor metastasis. The encoded protein may play an important role in embryogenesis, particularly in neuronal cells, as well as in lymphocyte development and survival. [provided by RefSeq, May 2013].
UniProt Summary: Plays a specialized role in the generation of left-right asymmetry during embryogenesis. May act as a negative regulator of the NOTCH-signaling pathway (PubMed:26429889, PubMed:26437028). Cleaves alpha-1-antitrypsin (PubMed:12617721). {ECO:0000269|PubMed:12617721, ECO:0000269|PubMed:26429889, ECO:0000269|PubMed:26437028}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

collagen catabolic process
coronary vasculature development
collagen metabolic process
determination of heart left/right asymmetry
hematopoietic progenitor cell differentiation
metalloendopeptidase activity
determination of left/right symmetry
determination of bilateral symmetry
specification of symmetry
extracellular matrix
extracellular matrix organization
extracellular structure organization
pattern specification process
blood vessel development
vasculature development
cardiovascular system development
heart development
hemopoiesis
hematopoietic or lymphoid organ development
immune system development
zinc ion binding
circulatory system development
proteolysis