MPLKIP

Gene Information
  • Official Symbol: MPLKIP
  • Official Name: M-phase specific PLK1 interacting protein
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 136647
  • UniProt: Q8TAP9
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: The protein encoded by this gene localizes to the centrosome during mitosis and to the midbody during cytokinesis. The protein is phosphorylated by cyclin-dependent kinase 1 during mitosis and subsequently interacts with polo-like kinase 1. The protein is thought to function in regulating mitosis and cytokinesis. Mutations in this gene result in nonphotosensitive trichothiodystrophy. [provided by RefSeq, Nov 2009].
  • UniProt Summary: May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis. {ECO:0000269|PubMed:17310276}.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 14619
  • Expression level (log2 read counts): 5.55

Expression Distribution

  • Last modified: 2025/12/10 20:19
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