MST1

Gene Information

Official Symbol: MST1
Official Name: macrophage stimulating 1
Aliases and Previous Symbols: N/A
Entrez ID: 4485
UniProt: P26927
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any proteolytic activity. The receptor for this protein is RON tyrosine kinase, which upon activation stimulates ciliary motility of ciliated epithelial lung cells. This protein is secreted and cleaved to form an alpha chain and a beta chain bridged by disulfide bonds. [provided by RefSeq, Jan 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 66/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	3/28
blood	5/28
bone	5/26
breast	1/33
central nervous system	1/56
cervix	0/4
colorectal	4/17
esophagus	2/13
fibroblast	0/1
gastric	1/16
kidney	0/21
liver	3/20
lung	8/75
lymphocyte	3/16
ovary	0/26
pancreas	2/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	1/1
skin	3/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	4/29
uterus	1/5

Essentiality in NALM6

Essentiality Rank: 3096
Expression level (log2 read counts): 2.99

Expression Distribution

Kringle
PAN 1
Trypsin

positive regulation of mammary gland epithelial cell proliferation
hepatocyte growth factor receptor signaling pathway
regulation of cAMP-dependent protein kinase activity
negative regulation of gluconeogenesis
regulation of mammary gland epithelial cell proliferation
regulation of macrophage chemotaxis
regulation of macrophage migration
negative regulation of cellular carbohydrate metabolic process
regulation of gluconeogenesis
negative regulation of carbohydrate metabolic process
receptor tyrosine kinase binding
negative regulation of small molecule metabolic process
regulation of carbohydrate biosynthetic process
regulation of leukocyte chemotaxis
regulation of glucose metabolic process
regulation of cellular carbohydrate metabolic process
serine-type endopeptidase activity
positive regulation of epithelial cell proliferation
regulation of leukocyte migration
regulation of carbohydrate metabolic process
regulation of chemotaxis
regulation of epithelial cell proliferation
collagen-containing extracellular matrix
regulation of small molecule metabolic process
transmembrane receptor protein tyrosine kinase signaling pathway
regulation of protein serine/threonine kinase activity
enzyme linked receptor protein signaling pathway
regulation of protein kinase activity
regulation of cell migration
regulation of kinase activity
regulation of cell motility
positive regulation of cell population proliferation
regulation of transferase activity
regulation of locomotion
regulation of cellular component movement
regulation of response to external stimulus
proteolysis
positive regulation of developmental process
regulation of protein phosphorylation
negative regulation of cellular biosynthetic process