MTHFS

Entrez Summary: The protein encoded by this gene is an enzyme that catalyzes the conversion of 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolate, a precursor of reduced folates involved in 1-carbon metabolism. An increased activity of the encoded protein can result in an increased folate turnover rate and folate depletion. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011].
UniProt Summary: Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10- methenyltetrahydrofolate. {ECO:0000269|PubMed:8522195}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

folic acid catabolic process
5-formyltetrahydrofolate cyclo-ligase activity
water-soluble vitamin catabolic process
pteridine-containing compound catabolic process
folic acid-containing compound catabolic process
formate metabolic process
folic acid-containing compound biosynthetic process
tetrahydrofolate interconversion
folic acid binding
vitamin catabolic process
pteridine-containing compound biosynthetic process
coenzyme catabolic process
dicarboxylic acid catabolic process
tetrahydrofolate metabolic process
folic acid metabolic process
one-carbon metabolic process
folic acid-containing compound metabolic process
cellular modified amino acid catabolic process
glutamate metabolic process
pteridine-containing compound metabolic process
cellular modified amino acid biosynthetic process
cofactor catabolic process
glutamine family amino acid metabolic process
water-soluble vitamin metabolic process
dicarboxylic acid metabolic process
antibiotic metabolic process
vitamin metabolic process
coenzyme biosynthetic process
drug catabolic process
cellular modified amino acid metabolic process
alpha-amino acid metabolic process
cofactor biosynthetic process
coenzyme metabolic process
carboxylic acid catabolic process
organic acid catabolic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
cellular amino acid metabolic process
mitochondrial matrix
heterocycle catabolic process