MUC20

Gene Information

Official Symbol: MUC20
Official Name: mucin 20, cell surface associated
Aliases and Previous Symbols: N/A
Entrez ID: 200958
UniProt: Q8N307
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins secreted by many epithelial tissues to form an insoluble mucous barrier. The C-terminus of this family member associates with the multifunctional docking site of the MET proto-oncogene and suppresses activation of some downstream MET signaling cascades. The protein features a mucin tandem repeat domain that varies between two and six copies in most individuals. Multiple variants encoding different isoforms have been found for this gene. A related pseudogene, which is also located on chromosome 3, has been identified. [provided by RefSeq, Apr 2014].
UniProt Summary: May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression. {ECO:0000269|PubMed:15314156}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2998
Expression level (log2 read counts): 5.68

Expression Distribution

hepatocyte growth factor receptor signaling pathway
microvillus membrane
basal plasma membrane
O-glycan processing
Golgi lumen
protein O-linked glycosylation
stimulatory C-type lectin receptor signaling pathway
innate immune response activating cell surface receptor signaling pathway
activation of MAPK activity
innate immune response-activating signal transduction
activation of innate immune response
protein glycosylation
macromolecule glycosylation
positive regulation of MAP kinase activity
glycosylation
apical plasma membrane
glycoprotein biosynthetic process
activation of protein kinase activity
positive regulation of protein serine/threonine kinase activity
protein homooligomerization
positive regulation of innate immune response
regulation of MAP kinase activity
positive regulation of response to biotic stimulus
glycoprotein metabolic process
immune response-activating cell surface receptor signaling pathway
regulation of innate immune response
positive regulation of defense response
immune response-regulating cell surface receptor signaling pathway
positive regulation of multi-organism process
transmembrane receptor protein tyrosine kinase signaling pathway
regulation of protein serine/threonine kinase activity
protein complex oligomerization
regulation of response to biotic stimulus
positive regulation of protein kinase activity
positive regulation of MAPK cascade
immune response-activating signal transduction
positive regulation of kinase activity
immune response-regulating signaling pathway
positive regulation of response to external stimulus
carbohydrate derivative biosynthetic process