MYL3

Entrez Summary: MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008].
UniProt Summary: Regulatory light chain of myosin. Does not bind calcium.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

myosin II heavy chain binding
A band
muscle myosin complex
I band
regulation of the force of heart contraction
actin monomer binding
actin-myosin filament sliding
muscle filament sliding
structural constituent of muscle
ventricular cardiac muscle tissue morphogenesis
sarcomere
ventricular cardiac muscle tissue development
positive regulation of ATPase activity
cardiac muscle tissue morphogenesis
cardiac ventricle morphogenesis
cardiac muscle contraction
muscle tissue morphogenesis
regulation of ATPase activity
muscle organ morphogenesis
heart contraction
actin-mediated cell contraction
regulation of striated muscle contraction
heart process
striated muscle contraction
actin filament-based movement
cardiac chamber morphogenesis
cardiac ventricle development
regulation of muscle contraction
cardiac muscle tissue development
cardiac chamber development
regulation of muscle system process
regulation of heart contraction
muscle contraction
heart morphogenesis
striated muscle tissue development
regulation of blood circulation
muscle organ development
muscle tissue development
muscle system process
blood circulation