NCS1

Entrez Summary: N/A
UniProt Summary: Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N- type voltage-gated calcium channel (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels
dense core granule
presynaptic cytosol
regulation of presynaptic cytosolic calcium ion concentration
postsynaptic cytosol
calyx of Held
neuron cellular homeostasis
voltage-gated calcium channel activity
phosphatidylinositol-mediated signaling
inositol lipid-mediated signaling
regulation of synaptic vesicle exocytosis
positive regulation of exocytosis
regulation of neurotransmitter secretion
regulation of synaptic vesicle cycle
regulation of neurotransmitter transport
regulation of regulated secretory pathway
calcium ion transmembrane transport
postsynaptic membrane
magnesium ion binding
regulation of exocytosis
calcium ion transport
postsynaptic density
divalent metal ion transport
divalent inorganic cation transport
regulation of cytosolic calcium ion concentration
anatomical structure homeostasis
glutamatergic synapse
regulation of neurotransmitter levels
positive regulation of secretion by cell
dendrite
positive regulation of secretion
cellular calcium ion homeostasis
modulation of chemical synaptic transmission
regulation of trans-synaptic signaling
calcium ion homeostasis
protein kinase binding
cellular divalent inorganic cation homeostasis
divalent inorganic cation homeostasis
regulation of neuron projection development
cell junction