NELL1

Entrez Summary: This gene encodes a cytoplasmic protein that contains epidermal growth factor (EGF)-like repeats. The encoded heterotrimeric protein may be involved in cell growth regulation and differentiation. A similar protein in rodents is involved in craniosynostosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013].
UniProt Summary: Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization. {ECO:0000269|PubMed:21723284}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of osteoblast proliferation
regulation of osteoblast proliferation
positive regulation of bone mineralization
positive regulation of biomineral tissue development
positive regulation of biomineralization
protein kinase C binding
positive regulation of osteoblast differentiation
regulation of bone mineralization
positive regulation of ossification
negative regulation of cellular protein catabolic process
regulation of biomineralization
regulation of biomineral tissue development
regulation of osteoblast differentiation
negative regulation of protein catabolic process
heparin binding
nuclear envelope
regulation of ossification
regulation of cellular protein catabolic process
negative regulation of cellular catabolic process
negative regulation of catabolic process
regulation of protein catabolic process
negative regulation of cell population proliferation
perinuclear region of cytoplasm
calcium ion binding
regulation of cellular catabolic process
positive regulation of cell differentiation
regulation of catabolic process
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
positive regulation of developmental process
regulation of cell population proliferation
positive regulation of multicellular organismal process
regulation of cell differentiation
extracellular region