NPY1R

Entrez Summary: N/A
UniProt Summary: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

7TM GPCR Srsx
7tm 1

peptide YY receptor activity
pancreatic polypeptide receptor activity
neuropeptide Y receptor activity
regulation of multicellular organism growth
outflow tract morphogenesis
sensory perception of pain
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
feeding behavior
neuropeptide signaling pathway
glucose metabolic process
hexose metabolic process
regulation of blood pressure
locomotory behavior
monosaccharide metabolic process
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
heart morphogenesis
regulation of developmental growth
blood circulation
circulatory system process
carbohydrate metabolic process
heart development
behavior
regulation of growth
circulatory system development
animal organ morphogenesis
sensory perception
G protein-coupled receptor signaling pathway
nervous system process
integral component of plasma membrane
small molecule metabolic process
system process