OLIG2

Entrez Summary: This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. [provided by RefSeq, Jul 2008].
UniProt Summary: Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

spinal cord oligodendrocyte cell differentiation
spinal cord oligodendrocyte cell fate specification
glial cell fate specification
oligodendrocyte cell fate commitment
oligodendrocyte cell fate specification
thalamus development
glial cell fate commitment
HMG box domain binding
positive regulation of oligodendrocyte differentiation
spinal cord motor neuron differentiation
regulation of oligodendrocyte differentiation
positive regulation of glial cell differentiation
ventral spinal cord development
cell differentiation in spinal cord
neuron fate commitment
positive regulation of gliogenesis
oligodendrocyte differentiation
regulation of glial cell differentiation
diencephalon development
cell fate specification
myelination
spinal cord development
ensheathment of neurons
axon ensheathment
regulation of gliogenesis
glial cell differentiation
central nervous system neuron differentiation
gliogenesis
negative regulation of neuron differentiation
cell fate commitment
negative regulation of neurogenesis
negative regulation of nervous system development
negative regulation of cell development
forebrain development
positive regulation of neurogenesis
positive regulation of nervous system development
positive regulation of cell development
regulation of neuron differentiation
negative regulation of cell differentiation
brain development