PADI6

Entrez Summary: This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. This protein may play a role in cytoskeletal reorganization in the egg and in early embryo development. [provided by RefSeq, Sep 2012].
UniProt Summary: Catalyzes the deimination of arginine residues of proteins (By similarity). May be involved in cytoskeletal reorganization in the egg and early embryo (PubMed:27545678). {ECO:0000250, ECO:0000269|PubMed:27545678}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Expression Distribution

regulation of translation by machinery localization
protein-arginine deiminase activity
histone citrullination
protein citrullination
cytoplasm organization
peptidyl-arginine modification
intermediate filament cytoskeleton
regulation of translation
histone modification
covalent chromatin modification
translation
regulation of cellular amide metabolic process
peptide biosynthetic process
posttranscriptional regulation of gene expression
amide biosynthetic process
peptide metabolic process
chromatin organization
calcium ion binding
cellular amide metabolic process
peptidyl-amino acid modification
chromosome organization
cytoskeleton organization
organonitrogen compound biosynthetic process
cellular protein localization
cellular macromolecule localization
cellular nitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
gene expression