PAQR8

Entrez Summary: N/A
UniProt Summary: Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432). Seems to act through a G(i) mediated pathway (PubMed:23763432). May be involved in oocyte maturation (By similarity). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (PubMed:23161870). {ECO:0000250|UniProtKB:Q80ZE5, ECO:0000269|PubMed:23161870, ECO:0000303|PubMed:23763432}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

steroid binding
steroid hormone receptor activity
oogenesis
steroid hormone mediated signaling pathway
female gamete generation
hormone-mediated signaling pathway
cellular response to steroid hormone stimulus
signaling receptor activity
germ cell development
response to steroid hormone
cellular process involved in reproduction in multicellular organism
cellular response to lipid
cellular response to organic cyclic compound
cellular response to hormone stimulus
developmental process involved in reproduction
gamete generation
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
response to lipid
response to hormone
response to organic cyclic compound
Golgi apparatus
multi-organism reproductive process
cellular response to endogenous stimulus
reproductive process
reproduction
response to endogenous stimulus
cell development