PDCD1LG2

Gene Information

Official Symbol: PDCD1LG2
Official Name: programmed cell death 1 ligand 2
Aliases and Previous Symbols: N/A
Entrez ID: 80380
UniProt: Q9BQ51
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Involved in the costimulatory signal, essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17432
Expression level (log2 read counts): -2.35

Expression Distribution

Screen	Score
Dynasore 10μM R04 exp180	-1.79
ABT-702 5μM R07 exp318	1.8

negative regulation of activated T cell proliferation
negative regulation of interleukin-10 production
negative regulation of interferon-gamma production
regulation of activated T cell proliferation
regulation of interleukin-10 production
T cell costimulation
lymphocyte costimulation
negative regulation of T cell proliferation
negative regulation of mononuclear cell proliferation
negative regulation of lymphocyte proliferation
endomembrane system
negative regulation of leukocyte proliferation
positive regulation of T cell proliferation
regulation of interferon-gamma production
negative regulation of T cell activation
negative regulation of leukocyte cell-cell adhesion
positive regulation of lymphocyte proliferation
positive regulation of mononuclear cell proliferation
positive regulation of leukocyte proliferation
negative regulation of lymphocyte activation
regulation of T cell proliferation
negative regulation of cell-cell adhesion
negative regulation of leukocyte activation
cellular response to lipopolysaccharide
cellular response to molecule of bacterial origin
negative regulation of cell activation
positive regulation of T cell activation
regulation of lymphocyte proliferation
regulation of mononuclear cell proliferation
cellular response to biotic stimulus
positive regulation of leukocyte cell-cell adhesion
regulation of leukocyte proliferation
positive regulation of cell-cell adhesion
negative regulation of cell adhesion
negative regulation of cytokine production
regulation of leukocyte cell-cell adhesion
response to lipopolysaccharide
regulation of T cell activation
response to molecule of bacterial origin
positive regulation of lymphocyte activation