PDE10A

Entrez Summary: The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2011].
UniProt Summary: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition. {ECO:0000250|UniProtKB:Q8CA95, ECO:0000269|PubMed:17389385}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

PDEase I
GAF

cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
cGMP catabolic process
negative regulation of cGMP-mediated signaling
3,5-cyclic-nucleotide phosphodiesterase activity
cAMP catabolic process
regulation of cGMP-mediated signaling
cyclic nucleotide catabolic process
3,5-cyclic-GMP phosphodiesterase activity
cGMP binding
cGMP metabolic process
regulation of protein kinase A signaling
cAMP metabolic process
cAMP binding
negative regulation of cAMP-mediated signaling
purine ribonucleotide catabolic process
ribonucleotide catabolic process
cyclic nucleotide metabolic process
purine nucleotide catabolic process
regulation of cAMP-mediated signaling
purine-containing compound catabolic process
nucleotide catabolic process
nucleoside phosphate catabolic process
nucleobase-containing small molecule biosynthetic process
organophosphate catabolic process
perikaryon
carbohydrate derivative catabolic process
purine ribonucleotide metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
purine-containing compound metabolic process
nucleobase-containing compound catabolic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process
organic cyclic compound catabolic process
negative regulation of intracellular signal transduction
nucleobase-containing small molecule metabolic process