PFN4

Entrez Summary: N/A
UniProt Summary: Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidic acid (PA). Does not bind to actin (PubMed:19419568), contrary to other family members. {ECO:0000269|PubMed:19419568}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

sequestering of actin monomers
actin monomer binding
negative regulation of actin filament polymerization
negative regulation of protein polymerization
maintenance of protein location in cell
maintenance of location in cell
maintenance of protein location
negative regulation of supramolecular fiber organization
negative regulation of protein complex assembly
cell cortex
negative regulation of cytoskeleton organization
lipid binding
maintenance of location
regulation of actin filament polymerization
regulation of actin polymerization or depolymerization
regulation of actin filament length
regulation of protein polymerization
regulation of actin filament organization
regulation of actin cytoskeleton organization
regulation of supramolecular fiber organization
cytoskeleton
negative regulation of organelle organization
regulation of cellular component size
regulation of actin filament-based process
regulation of protein complex assembly
regulation of anatomical structure size
regulation of cytoskeleton organization
negative regulation of cellular component organization
regulation of cellular component biogenesis
regulation of organelle organization
cellular protein localization
cellular macromolecule localization