PGD

Entrez Summary: N/A
UniProt Summary: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 465/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	14/28
blood	24/28
bone	11/26
breast	27/33
central nervous system	25/56
cervix	3/4
colorectal	10/17
esophagus	7/13
fibroblast	0/1
gastric	13/16
kidney	16/21
liver	10/20
lung	55/75
lymphocyte	14/16
ovary	14/26
pancreas	17/24
peripheral nervous system	8/16
plasma cell	14/15
prostate	0/1
skin	20/24
soft tissue	4/9
thyroid	1/2
upper aerodigestive	11/22
urinary tract	14/29
uterus	3/5

Expression Distribution

6PGD
NAD binding 2

phosphogluconate dehydrogenase (decarboxylating) activity
D-gluconate catabolic process
aldonic acid metabolic process
aldonic acid catabolic process
D-gluconate metabolic process
pentose-phosphate shunt, oxidative branch
pentose biosynthetic process
pentose-phosphate shunt
pentose metabolic process
NADPH regeneration
glucose 6-phosphate metabolic process
NADP metabolic process
NADP binding
cellular carbohydrate catabolic process
monosaccharide biosynthetic process
monocarboxylic acid catabolic process
carbohydrate catabolic process
carbohydrate biosynthetic process
cellular carbohydrate metabolic process
monosaccharide metabolic process
carboxylic acid catabolic process
organic acid catabolic process
generation of precursor metabolites and energy
small molecule catabolic process
carbohydrate metabolic process
monocarboxylic acid metabolic process
small molecule biosynthetic process
organophosphate metabolic process
carboxylic acid metabolic process
oxidation-reduction process
oxoacid metabolic process
organic acid metabolic process
carbohydrate derivative metabolic process
small molecule metabolic process
organic substance catabolic process
cellular catabolic process