PLA2G6
Gene Information
- Official Symbol: PLA2G6
- Official Name: phospholipase A2 group VI
- Aliases and Previous Symbols: N/A
- Entrez ID: 8398
- UniProt: O60733
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only three of them have been determined to date. [provided by RefSeq, Dec 2010].
- UniProt Summary: Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F- actin polymerization at the pseudopods.
Pfam Domains GO Terms
Pfam Domains
| Ank |
| Ank 2 |
| Patatin |
GO Terms
| serine hydrolase activity |
| positive regulation of arachidonic acid secretion |
| calcium-independent phospholipase A2 activity |
| urinary tract smooth muscle contraction |
| urinary bladder smooth muscle contraction |
| cardiolipin biosynthetic process |
| ATP-dependent protein binding |
| regulation of arachidonic acid secretion |
| phosphatidylglycerol biosynthetic process |
| negative regulation of synaptic transmission, glutamatergic |
| regulation of store-operated calcium channel activity |
| positive regulation of sphingolipid biosynthetic process |
| positive regulation of protein kinase C signaling |
| positive regulation of ceramide biosynthetic process |
| cardiolipin metabolic process |
| regulation of protein kinase C signaling |
| regulation of membrane lipid metabolic process |
| regulation of ceramide biosynthetic process |
| regulation of sphingolipid biosynthetic process |
| positive regulation of icosanoid secretion |
| positive regulation of fatty acid transport |
| regulation of icosanoid secretion |
| phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) |
| phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) |
| phosphatidylethanolamine acyl-chain remodeling |
| regulation of fatty acid transport |
| phosphatidylcholine acyl-chain remodeling |
| phospholipase A2 activity |
| positive regulation of release of cytochrome c from mitochondria |
| phosphatidylglycerol metabolic process |
| positive regulation of insulin secretion involved in cellular response to glucose stimulus |
| positive regulation of organic acid transport |
| antibacterial humoral response |
| regulation of release of cytochrome c from mitochondria |
| positive regulation of anion transport |
| smooth muscle contraction |
| regulation of insulin secretion involved in cellular response to glucose stimulus |
| positive regulation of blood vessel diameter |
| regulation of organic acid transport |
| negative regulation of synaptic transmission |
| positive regulation of lipid transport |
| maternal process involved in female pregnancy |
| regulation of synaptic transmission, glutamatergic |
| positive regulation of insulin secretion |
| phosphatidylcholine metabolic process |
| hydrolase activity |
| positive regulation of lipid biosynthetic process |
| positive regulation of lipid localization |
| regulation of calcium ion transmembrane transporter activity |
| positive regulation of exocytosis |
| regulation of anion transport |
| positive regulation of peptide hormone secretion |
| regulation of lipid transport |
| antimicrobial humoral response |
| positive regulation of mitochondrion organization |
| memory |
| positive regulation of hormone secretion |
| immune response-regulating cell surface receptor signaling pathway involved in phagocytosis |
| Fc-gamma receptor signaling pathway involved in phagocytosis |
| Fc receptor mediated stimulatory signaling pathway |
| regulation of lipid localization |
| regulation of blood vessel diameter |
| regulation of tube diameter |
| Fc-gamma receptor signaling pathway |
| regulation of tube size |
| positive regulation of lipid metabolic process |
| regulation of calcium ion transmembrane transport |
| positive regulation of cellular amide metabolic process |
| microtubule organizing center |
| vascular process in circulatory system |
| regulation of cation channel activity |
| positive regulation of apoptotic signaling pathway |
| regulation of insulin secretion |
| female pregnancy |
| regulation of mitochondrion organization |
| regulation of lipid biosynthetic process |
| ammonium ion metabolic process |
| calmodulin binding |
| glycerophospholipid biosynthetic process |
| regulation of peptide hormone secretion |
| multi-multicellular organism process |
| glycerolipid biosynthetic process |
| regulation of exocytosis |
| Fc receptor signaling pathway |
| phospholipid biosynthetic process |
| regulation of calcium ion transport |
| muscle contraction |
| response to endoplasmic reticulum stress |
| regulation of ion transmembrane transporter activity |
| learning or memory |
| regulation of transmembrane transporter activity |
| regulation of hormone secretion |
| positive regulation of protein secretion |
| positive regulation of ion transport |
| regulation of transporter activity |
| positive regulation of cytosolic calcium ion concentration |
| positive regulation of peptide secretion |
| cognition |
| lipid catabolic process |
| muscle system process |
| glycerophospholipid metabolic process |
| regulation of cytosolic calcium ion concentration |
| phagocytosis |
| defense response to bacterium |
| regulation of cation transmembrane transport |
| humoral immune response |
| phospholipid metabolic process |
| glycerolipid metabolic process |
| regulation of metal ion transport |
| blood circulation |
| regulation of lipid metabolic process |
| circulatory system process |
| regulation of apoptotic signaling pathway |
| positive regulation of secretion by cell |
| regulation of cellular amide metabolic process |
| positive regulation of protein transport |
| positive regulation of secretion |
| cellular calcium ion homeostasis |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| calcium ion homeostasis |
| immune response-activating cell surface receptor signaling pathway |
| positive regulation of establishment of protein localization |
| protein kinase binding |
| regulation of protein secretion |
| cellular divalent inorganic cation homeostasis |
| regulation of ion transmembrane transport |
| immune response-regulating cell surface receptor signaling pathway |
| divalent inorganic cation homeostasis |
| regulation of peptide secretion |
| regulation of anatomical structure size |
| regulation of hormone levels |
| organophosphate biosynthetic process |
| regulation of vesicle-mediated transport |
| chemotaxis |
| taxis |
| cellular metal ion homeostasis |
| immune response-activating signal transduction |
| regulation of transmembrane transport |
| behavior |
| lipid biosynthetic process |
| immune response-regulating signaling pathway |
| positive regulation of organelle organization |
| metal ion homeostasis |
| activation of immune response |
| cellular cation homeostasis |
| positive regulation of apoptotic process |
| cellular ion homeostasis |
| positive regulation of programmed cell death |
| response to bacterium |
| positive regulation of cell death |
| regulation of ion transport |
| regulation of protein transport |
| cation homeostasis |
| inorganic ion homeostasis |
| regulation of peptide transport |
| cellular chemical homeostasis |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| ion homeostasis |
| regulation of secretion |
| multicellular organismal reproductive process |
| multicellular organism reproduction |
| positive regulation of immune response |
| organophosphate metabolic process |
| cellular homeostasis |
| regulation of cellular localization |
| defense response to other organism |
| cellular lipid metabolic process |
| regulation of cellular component biogenesis |
| positive regulation of transport |
| multi-organism reproductive process |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| regulation of protein localization |
| positive regulation of phosphorylation |
| immune effector process |
| chemical homeostasis |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of immune system process |
| regulation of immune response |
| positive regulation of cellular component organization |
| lipid metabolic process |
| positive regulation of protein modification process |
| mitochondrion |
| regulation of organelle organization |
| response to other organism |
| response to external biotic stimulus |
| locomotion |
| response to biotic stimulus |
| defense response |
| negative regulation of cell communication |
| negative regulation of signaling |
| nervous system process |
| reproductive process |
| reproduction |
| regulation of protein phosphorylation |
| regulation of apoptotic process |
| regulation of programmed cell death |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| homeostatic process |
| regulation of immune system process |
| positive regulation of signal transduction |
| regulation of cell death |
| cellular response to stress |
| positive regulation of protein metabolic process |
| organic substance catabolic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
| immune response |
| vesicle-mediated transport |
| system process |
| positive regulation of cellular biosynthetic process |
| membrane |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Pyridostatin 4μM R05 exp240 | 1.8 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| POLR2J3 | 0.527 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2732
- Expression level (log2 read counts): 3.78
Expression Distribution
PLA2G6 Expression in NALM6 Cells: 3.78
