PLD1

Entrez Summary: This gene encodes a phosphatidylcholine-specific phospholipase which catalyzes the hydrolysis of phosphatidylcholine in order to yield phosphatidic acid and choline. The enzyme may play a role in signal transduction and subcellular trafficking. Alternative splicing results in multiple transcript variants with both catalytic and regulatory properties. [provided by RefSeq, Sep 2011].
UniProt Summary: Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
GSK461364A 0.1μM R03 exp126	-2.07
5-Fluorouracil 20μM R00 exp2	-1.99
BAY-598 4μM R05 exp220	1.7
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	1.99

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

N-acylphosphatidylethanolamine-specific phospholipase D activity
regulation of microvillus assembly
phospholipase D activity
cholinergic synapse
regulation of microvillus organization
phosphatidic acid biosynthetic process
phosphatidic acid metabolic process
endocytic vesicle
tertiary granule membrane
inositol lipid-mediated signaling
phosphatidylinositol binding
specific granule membrane
regulation of synaptic vesicle cycle
late endosome membrane
regulation of plasma membrane bounded cell projection assembly
regulation of cell projection assembly
glycerophospholipid biosynthetic process
glycerolipid biosynthetic process
phospholipid biosynthetic process
Ras protein signal transduction
endosome
lipid catabolic process
lysosomal membrane
glycerophospholipid metabolic process
apical plasma membrane
small GTPase mediated signal transduction
phospholipid metabolic process
glycerolipid metabolic process
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
organophosphate biosynthetic process
regulation of vesicle-mediated transport
chemotaxis
taxis