PROX2

Entrez Summary: N/A
UniProt Summary: Transcription regulator. Does not seem to be essential for embryonic development and postnatal survival (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

lens fiber cell morphogenesis
lymphatic endothelial cell differentiation
lymphangiogenesis
lens fiber cell development
lymph vessel morphogenesis
lymph vessel development
lens morphogenesis in camera-type eye
lens fiber cell differentiation
lens development in camera-type eye
endothelial cell differentiation
endothelium development
camera-type eye morphogenesis
eye morphogenesis
epithelial cell development
sensory organ morphogenesis
camera-type eye development
eye development
visual system development
sensory system development
vasculature development
cardiovascular system development
sensory organ development
cell morphogenesis involved in differentiation
epithelial cell differentiation
cell morphogenesis
cellular component morphogenesis
negative regulation of transcription by RNA polymerase II
circulatory system development
anatomical structure formation involved in morphogenesis
animal organ morphogenesis
epithelium development
negative regulation of transcription, DNA-templated
positive regulation of transcription by RNA polymerase II
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
DNA binding
negative regulation of macromolecule biosynthetic process