PRSS12
Gene Information
- Official Symbol: PRSS12
- Official Name: serine protease 12
- Aliases and Previous Symbols: N/A
- Entrez ID: 8492
- UniProt: P56730
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the trypsin family of serine proteases and contains a signal peptide, a proline-rich region, a Kringle domain, four scavenger receptor cysteine-rich domains, and a trypsin-like serine protease domain. The protein, sometimes referred to as neurotrypsin or motopsin, is secreted from neuronal cells and localizes to the synaptic cleft. Studies in mice show that this protein cleaves a protein, agrin, that is important for the formation and maintenance of exitatory synapses. Defects in this gene cause a form of autosomal recessive cognitive impairment (MRT1). [provided by RefSeq, Jul 2017].
- UniProt Summary: Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations. {ECO:0000250}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 8708
- Expression level (log2 read counts): -0.52
PRSS12 Expression in NALM6 Cells: -0.52
