PTGDR

Entrez Summary: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein is reported to be a receptor for prostaglandin D2, which is a mediator of allergic inflammation and allergic airway inflammation in asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
UniProt Summary: Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

prostaglandin D receptor activity
prostaglandin J receptor activity
cellular response to prostaglandin D stimulus
response to prostaglandin D
adenosine metabolic process
sleep
male sex determination
cellular response to prostaglandin stimulus
sex determination
response to prostaglandin
cellular response to fatty acid
purine ribonucleoside metabolic process
purine nucleoside metabolic process
ribonucleoside metabolic process
cellular response to alcohol
response to fatty acid
cellular response to ketone
nucleoside metabolic process
adenylate cyclase-activating G protein-coupled receptor signaling pathway
glycosyl compound metabolic process
cAMP-mediated signaling
cyclic-nucleotide-mediated signaling
response to ketone
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
cellular response to acid chemical
response to alcohol
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
positive regulation of cytosolic calcium ion concentration
regulation of cytosolic calcium ion concentration
second-messenger-mediated signaling
response to acid chemical
purine-containing compound metabolic process
cellular calcium ion homeostasis
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
divalent inorganic cation homeostasis
inflammatory response
drug metabolic process
cellular response to lipid
nucleobase-containing small molecule metabolic process