PTP4A3

Entrez Summary: N/A
UniProt Summary: Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II. {ECO:0000269|PubMed:11355880, ECO:0000269|PubMed:12782572}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Y phosphatase
DSPc

prenylated protein tyrosine phosphatase activity
positive regulation of vascular permeability
regulation of vascular endothelial growth factor signaling pathway
regulation of cellular response to vascular endothelial growth factor stimulus
regulation of vascular permeability
protein tyrosine/serine/threonine phosphatase activity
endothelial cell migration
positive regulation of NIK/NF-kappaB signaling
epithelial cell migration
epithelium migration
tissue migration
cellular response to leukemia inhibitory factor
response to leukemia inhibitory factor
protein tyrosine phosphatase activity
peptidyl-tyrosine dephosphorylation
regulation of NIK/NF-kappaB signaling
Notch signaling pathway
vascular process in circulatory system
ameboidal-type cell migration
protein dephosphorylation
early endosome
regulation of cellular response to growth factor stimulus
dephosphorylation
blood circulation
circulatory system process
positive regulation of establishment of protein localization
regulation of establishment of protein localization
cell migration
cellular response to cytokine stimulus
positive regulation of intracellular signal transduction
regulation of protein localization
cell motility
localization of cell
response to cytokine
locomotion
movement of cell or subcellular component
positive regulation of signal transduction
positive regulation of cell communication
positive regulation of signaling
regulation of intracellular signal transduction