PTPN9

Gene Information

Official Symbol: PTPN9
Official Name: protein tyrosine phosphatase non-receptor type 9
Aliases and Previous Symbols: N/A
Entrez ID: 5780
UniProt: P43378
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus. {ECO:0000269|PubMed:19167335}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 11598
Expression level (log2 read counts): 5.86

Expression Distribution

Screen	Score
Docosahexaenoic-acid 50μM R07 exp356	1.77
LY2090314 0.003μM R08 exp499	2.19

Y phosphatase
CRAL TRIO

non-membrane spanning protein tyrosine phosphatase activity
neuron projection terminus
positive regulation of protein localization to plasma membrane
positive regulation of protein localization to cell periphery
regulation of protein localization to plasma membrane
protein tyrosine phosphatase activity
peptidyl-tyrosine dephosphorylation
regulation of protein localization to cell periphery
positive regulation of protein localization to membrane
negative regulation of neuron projection development
negative regulation of cell projection organization
regulation of protein localization to membrane
protein dephosphorylation
negative regulation of neuron differentiation
negative regulation of neurogenesis
dephosphorylation
negative regulation of nervous system development
positive regulation of cellular protein localization
negative regulation of cell development
regulation of neuron projection development
regulation of cellular protein localization
regulation of neuron differentiation
regulation of plasma membrane bounded cell projection organization
negative regulation of cellular component organization
regulation of cell projection organization
negative regulation of cell differentiation
regulation of neurogenesis
regulation of cellular localization
regulation of nervous system development
regulation of cell development
negative regulation of developmental process
cellular response to cytokine stimulus
regulation of protein localization
response to cytokine
negative regulation of multicellular organismal process
generation of neurons
neurogenesis
regulation of cell differentiation