PXN

Entrez Summary: This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445). [provided by RefSeq, Aug 2011].
UniProt Summary: Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 19/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	2/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	2/16
kidney	1/21
liver	1/20
lung	2/75
lymphocyte	0/16
ovary	1/26
pancreas	2/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Expression Distribution

LIM
Paxillin

signal complex assembly
vinculin binding
neuropilin binding
growth hormone receptor signaling pathway
cellular response to growth hormone stimulus
microtubule associated complex
response to growth hormone
positive regulation of stress fiber assembly
substrate adhesion-dependent cell spreading
positive regulation of actin filament bundle assembly
adherens junction
endothelial cell migration
vascular endothelial growth factor receptor signaling pathway
stress fiber
regulation of stress fiber assembly
transcription coregulator activity
beta-catenin binding
epithelial cell migration
protein phosphatase binding
epithelium migration
regulation of actomyosin structure organization
regulation of actin filament bundle assembly
tissue migration
transforming growth factor beta receptor signaling pathway
cellular response to reactive oxygen species
integrin binding
cell cortex
cellular response to transforming growth factor beta stimulus
response to transforming growth factor beta
ameboidal-type cell migration
lamellipodium
cell-substrate adhesion
response to reactive oxygen species
positive regulation of supramolecular fiber organization
transmembrane receptor protein serine/threonine kinase signaling pathway
positive regulation of cytoskeleton organization
cellular response to oxidative stress
muscle contraction
regulation of actin filament organization
cellular response to peptide hormone stimulus