RAB26

Entrez Summary: N/A
UniProt Summary: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach. Plays a role in the secretion of amylase from acinar granules in the parotid gland. {ECO:0000269|PubMed:20038531, ECO:0000269|PubMed:23105096}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of protein catabolic process at presynapse, modulating synaptic transmission
GMP binding
anchored component of synaptic vesicle membrane
presynaptic modulation of chemical synaptic transmission
Golgi to plasma membrane protein transport
intrinsic component of plasma membrane
exocrine system development
establishment of protein localization to plasma membrane
Golgi to plasma membrane transport
Rab protein signal transduction
vesicle-mediated transport to the plasma membrane
secretory granule membrane
post-Golgi vesicle-mediated transport
protein localization to plasma membrane
regulation of exocytosis
protein localization to cell periphery
Ras protein signal transduction
establishment of protein localization to membrane
small GTPase mediated signal transduction
GTPase activity
Golgi vesicle transport
regulation of protein catabolic process
GTP binding
modulation of chemical synaptic transmission
regulation of trans-synaptic signaling
protein localization to membrane
regulation of vesicle-mediated transport
Golgi membrane
regulated exocytosis
regulation of secretion by cell
exocytosis
regulation of secretion
regulation of catabolic process
intracellular protein transport
secretion by cell
export from cell
secretion
protein transport
intracellular transport
peptide transport