RASGEF1A

Entrez Summary: N/A
UniProt Summary: Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, KRAS, HRAS, and NRAS (in vitro). Plays a role in cell migration. {ECO:0000269|PubMed:17121879, ECO:0000269|PubMed:19645719}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

RasGEF
RasGEF N

Ras guanyl-nucleotide exchange factor activity
positive regulation of Ras protein signal transduction
positive regulation of small GTPase mediated signal transduction
regulation of Ras protein signal transduction
small GTPase mediated signal transduction
regulation of small GTPase mediated signal transduction
MAPK cascade
signal transduction by protein phosphorylation
cell migration
protein phosphorylation
positive regulation of intracellular signal transduction
localization of cell
cell motility
phosphorylation
locomotion
movement of cell or subcellular component
positive regulation of signal transduction
intracellular signal transduction
positive regulation of cell communication
positive regulation of signaling
regulation of intracellular signal transduction