RNFT1

Entrez Summary: N/A
UniProt Summary: E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome- mediated degradation. Protects cells from ER stress-induced apoptosis. {ECO:0000269|PubMed:27485036}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of ERAD pathway
regulation of ERAD pathway
positive regulation of response to endoplasmic reticulum stress
protein autoubiquitination
ubiquitin binding
regulation of response to endoplasmic reticulum stress
positive regulation of proteasomal protein catabolic process
positive regulation of proteolysis involved in cellular protein catabolic process
positive regulation of cellular protein catabolic process
regulation of proteasomal protein catabolic process
regulation of proteolysis involved in cellular protein catabolic process
positive regulation of protein catabolic process
ubiquitin protein ligase activity
regulation of cellular protein catabolic process
positive regulation of proteolysis
positive regulation of cellular catabolic process
regulation of protein catabolic process
positive regulation of catabolic process
protein ubiquitination
regulation of proteolysis
regulation of cellular response to stress
protein modification by small protein conjugation
regulation of cellular catabolic process
endoplasmic reticulum membrane
protein modification by small protein conjugation or removal
regulation of catabolic process
endoplasmic reticulum
regulation of response to stress
positive regulation of cellular protein metabolic process
positive regulation of protein metabolic process