RRAD

Official Symbol: RRAD
Official Name: RRAD, Ras related glycolysis inhibitor and calcium channel regulator
Aliases and Previous Symbols: N/A
Entrez ID: 6236
UniProt: P55042
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: N/A
UniProt Summary: May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha- 1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D. {ECO:0000250, ECO:0000269|PubMed:18056528}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Miro
Ras

negative regulation of high voltage-gated calcium channel activity
negative regulation of voltage-gated calcium channel activity
regulation of high voltage-gated calcium channel activity
negative regulation of calcium ion transmembrane transporter activity
regulation of voltage-gated calcium channel activity
calcium channel regulator activity
negative regulation of calcium ion transmembrane transport
negative regulation of cation channel activity
negative regulation of calcium ion transport
negative regulation of ion transmembrane transporter activity
negative regulation of transporter activity
negative regulation of cation transmembrane transport
regulation of calcium ion transmembrane transporter activity
negative regulation of ion transmembrane transport
negative regulation of transmembrane transport
negative regulation of ion transport
regulation of calcium ion transmembrane transport
regulation of cation channel activity
calmodulin binding
regulation of calcium ion transport
regulation of ion transmembrane transporter activity
regulation of transmembrane transporter activity
regulation of transporter activity
small GTPase mediated signal transduction
GTPase activity
regulation of cation transmembrane transport
regulation of metal ion transport
GTP binding
regulation of ion transmembrane transport
negative regulation of transport
regulation of transmembrane transport
regulation of ion transport
negative regulation of molecular function
intracellular signal transduction
regulation of transport