SC5D

Entrez Summary: This gene encodes an enzyme of cholesterol biosynthesis. The encoded protein catalyzes the conversion of lathosterol into 7-dehydrocholesterol. Mutations in this gene have been associated with lathosterolosis. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008].
UniProt Summary: Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

C-5 sterol desaturase activity
cholesterol biosynthetic process via lathosterol
cholesterol biosynthetic process via desmosterol
cholesterol biosynthetic process
regulation of sterol biosynthetic process
regulation of cholesterol biosynthetic process
secondary alcohol biosynthetic process
sterol biosynthetic process
regulation of cholesterol metabolic process
regulation of alcohol biosynthetic process
regulation of steroid biosynthetic process
alcohol biosynthetic process
regulation of steroid metabolic process
cholesterol metabolic process
steroid biosynthetic process
secondary alcohol metabolic process
iron ion binding
sterol metabolic process
organic hydroxy compound biosynthetic process
regulation of lipid biosynthetic process
steroid metabolic process
alcohol metabolic process
regulation of lipid metabolic process
regulation of small molecule metabolic process
organic hydroxy compound metabolic process
lipid biosynthetic process
small molecule biosynthetic process
endoplasmic reticulum membrane
oxidation-reduction process
lipid metabolic process
organic cyclic compound biosynthetic process
small molecule metabolic process