SERPIND1
Gene Information
- Official Symbol: SERPIND1
- Official Name: serpin family D member 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 3053
- UniProt: P05546
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene belongs to the serpin gene superfamily. Serpins play roles in many processes including inflammation, blood clotting, and cancer metastasis. Members of this family have highly conserved secondary structures with a reactive center loop that interacts with the protease active site to inhibit protease activity. This gene encodes a plasma serine protease that functions as a thrombin and chymotrypsin inhibitor. The protein is activated by heparin, dermatan sulfate, and glycosaminoglycans. Allelic variations in this gene are associated with heparin cofactor II deficiency. [provided by RefSeq, Jul 2015].
- UniProt Summary: Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. {ECO:0000269|PubMed:1939083}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 9767
- Expression level (log2 read counts): -1.52
SERPIND1 Expression in NALM6 Cells: -1.52
