SETD6

Entrez Summary: N/A
UniProt Summary: Protein-lysine N-methyltransferase. Monomethylates 'Lys- 310' of the RELA subunit of NF-kappa-B complex, leading to down- regulate NF-kappa-B transcription factor activity (PubMed:21131967). Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) (PubMed:23324626). Required for the maintenance of embryonic stem cell self-renewal (By similarity). {ECO:0000250|UniProtKB:Q9CWY3, ECO:0000269|PubMed:21131967, ECO:0000269|PubMed:23324626}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Rubis-subs-bind
SET

peptidyl-lysine monomethylation
protein-lysine N-methyltransferase activity
NF-kappaB binding
histone lysine methylation
negative regulation of NF-kappaB transcription factor activity
peptidyl-lysine methylation
histone methylation
protein alkylation
protein methylation
stem cell population maintenance
maintenance of cell number
stem cell differentiation
negative regulation of DNA-binding transcription factor activity
macromolecule methylation
methylation
peptidyl-lysine modification
regulation of inflammatory response
histone modification
covalent chromatin modification
regulation of DNA-binding transcription factor activity
chromatin organization
regulation of defense response
peptidyl-amino acid modification
chromosome organization
regulation of response to external stimulus
negative regulation of molecular function
regulation of response to stress