SIGIRR

Gene Information

Official Symbol: SIGIRR
Official Name: single Ig and TIR domain containing
Aliases and Previous Symbols: N/A
Entrez ID: 59307
UniProt: Q6IA17
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP. {ECO:0000269|PubMed:12925853, ECO:0000269|PubMed:14715412, ECO:0000269|PubMed:15866876, ECO:0000269|PubMed:25963006}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3458
Expression level (log2 read counts): 2.27

Expression Distribution

Screen	Score
Vemurafenib 6.6μM R02 exp89	1.72
MS094 2μM R03 exp136	1.87
CB-839 10μM R05 exp224	2.05

negative regulation of chemokine biosynthetic process
negative regulation of lipopolysaccharide-mediated signaling pathway
regulation of chemokine biosynthetic process
negative regulation of chemokine production
regulation of lipopolysaccharide-mediated signaling pathway
negative regulation of cytokine biosynthetic process
acute-phase response
negative regulation of cytokine-mediated signaling pathway
negative regulation of response to cytokine stimulus
acute inflammatory response
regulation of chemokine production
negative regulation of response to biotic stimulus
regulation of cytokine biosynthetic process
negative regulation of DNA-binding transcription factor activity
regulation of cytokine-mediated signaling pathway
regulation of response to cytokine stimulus
negative regulation of multi-organism process
negative regulation of cytokine production
negative regulation of response to external stimulus
regulation of DNA-binding transcription factor activity
inflammatory response
regulation of response to biotic stimulus
regulation of cytokine production
regulation of multi-organism process
cellular response to cytokine stimulus
regulation of response to external stimulus
response to cytokine
negative regulation of protein metabolic process
negative regulation of molecular function
negative regulation of multicellular organismal process
negative regulation of signal transduction
defense response
negative regulation of cell communication
negative regulation of signaling
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
negative regulation of response to stimulus
membrane