SIPA1

Entrez Summary: N/A
UniProt Summary: GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state (PubMed:9346962). Affects cell cycle progression (By similarity). {ECO:0000250|UniProtKB:P46062, ECO:0000269|PubMed:9346962}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Rap GAP
PDZ

cellular response to water deprivation
cellular response to water stimulus
response to water deprivation
response to water
transport vesicle
negative regulation of cell growth
protein C-terminus binding
cellular response to acid chemical
negative regulation of growth
cellular response to extracellular stimulus
negative regulation of cell adhesion
GTPase activator activity
cellular response to environmental stimulus
cellular response to abiotic stimulus
cellular response to external stimulus
response to acid chemical
regulation of small GTPase mediated signal transduction
positive regulation of GTPase activity
regulation of cell growth
regulation of GTPase activity
response to extracellular stimulus
response to inorganic substance
negative regulation of cell cycle
protein-containing complex
regulation of growth
regulation of cell adhesion
perinuclear region of cytoplasm
positive regulation of hydrolase activity
cellular response to oxygen-containing compound
cytoskeleton organization
response to abiotic stimulus
regulation of cell cycle
regulation of hydrolase activity
positive regulation of catalytic activity
response to oxygen-containing compound
intracellular signal transduction
cellular response to stress
positive regulation of molecular function
regulation of intracellular signal transduction
membrane